General Information

  • ID:  hor006031
  • Uniprot ID:  Q10757
  • Protein name:  Angiotensin
  • Gene name:  NA
  • Organism:  Theromyzon tessulatum (Duck leech)
  • Family:  Serpin family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:   Theromyzon (genus), Glossiphoniidae (family), Rhynchobdellida (order), Hirudinea (subclass), Clitellata (class), Annelida (phylum), Lophotrochozoa , Spiralia , Protostomia , Bilateria , Eumetazoa , Metazoa (kingdom), Opisthokonta , Eukaryota (superkingdom),cellular organisms
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  DRVYIHPFHLLXWG
  • Length:  14
  • Propeptide:  DRVYIHPFHLLXWG
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  In leeches, the angiotensins are involved in diuresis.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    hor006031_AF2.pdbhor006031_ESM.pdb

Physical Information

Mass: 197697 Formula: C81H111N21O16
Absent amino acids: ACEKMNQST Common amino acids: HL
pI: 7.71 Basic residues: 3
Polar residues: 2 Hydrophobic residues: 6
Hydrophobicity: 3.57 Boman Index: -805
Half-Life: 1.1 hour Half-Life Yeast: 3 min
Half-Life E.Coli: >10 hour Aliphatic Index 104.29
Instability Index: 1019.29 Extinction Coefficient cystines: 6990
Absorbance 280nm: 537.69

Literature

  • PubMed ID:  7637887
  • Title:  A comparison of the leech Theromyzon tessulatum angiotensin I-like molecule with forms of vertebrate angiotensinogens: a hormonal system conserved in the course of evolution.
  • PubMed ID:  8612806
  • Title:  Metabolism of angiotensins by head membranes of the leech Theromyzon tessulatum.